Relieve Us of This Burthen is the first book-length study of Continental soldiers, officers, and militiamen held as prisoners of war by the British in the South during the American Revolution. Carl P. Borick focuses his study on the period 1780-82, when British forces most actively campaigned in the South. He gives a detailed examination of the various hardships of imprisonment and efforts to assist and exchange prisoners while also chronicling events and military policies that affected prisoners during and after captivity.

As have prisoners of any war, captives in the Revolution suffered both physical and mental adversities during their imprisonments, and the impact often stayed with them after their release. Many escaped their captors or broke paroles to fight again. Others were exchanged; still others enlisted in British forces sent to the West Indies, and many died in prison. Because of the intense combat in South Carolina, more Americans were taken prisoner there than elsewhere across the Southern Department. Borick concentrates much of his narrative on Charleston and the lowcountry. Some 6,000 Continentals, militia, and seamen were captured when Charleston surrendered in May 1780. This was the largest number of prisoners taken during a single operation. Occupied Charleston became the key prisoner depot for the British in the South.

Borick also explores British recruiting efforts among prisoners, particularly by the Duke of Cumberland's Regiment, raised from prisoners kept in Charleston for service in the West Indies against the French and Spanish. That regiment's experiences during and after the war were far different from those of other American soldiers in the Revolutionary War.