During the Civil War, both sides believed that whoever controlled the Mississippi River would ultimately be victorious. Cotton exports generated much-needed revenue for the Confederacy, and the Mississippi was also the main conduit for the delivery of materials and food. Similarly, the Union sought to maintain safe passage from St. Louis, Missouri, to Cairo, Illinois, but also worked to bisect the South by seizing the river as part of the Anaconda Plan.

Drawing heavily on the diaries and letters of officers and common sailors, Barbara Brooks Tomblin explores the years during which the Union navy fought to win control of the Mississippi. Her approach provides fresh insight into major battles such as Memphis and Vicksburg, but also offers fascinating perspectives on lesser-known aspects of the conflict from ordinary sailors engaged in brown-water warfare. These men speak of going ashore in foraging parties, assisting the surgeon in the amputation of a fellow crewman's arm, and liberating supplies of whiskey from captured enemy vessels. The Civil War on the Mississippi not only provides listeners with a comprehensive and vivid account of the action on the western rivers; it also offers an incredible synthesis of first-person accounts from the front lines.