The Johnson and Johnson Vaccine against COVID 19 was approved for Emergency Use Authorization in the United States on Saturday Feb 27, 2021. The main questions are does the clinical trial data show that the vaccine offers meaningful, measurable protection from Covid-19 disease? After this vaccine is administered, will it cause fewer people to get sick, cause fewer people to get severely ill from Covid-19, or cause fewer people to transmit the virus after exposure? The initial release of findings from clinical trials was meant with disappointment because the vaccine showed only a 66% efficacy against the disease a general population. But if you have been listening to this podcast, in particular, "Episode 10: Which COVID-19 vaccine is the best for you?” and “Episode 12: How Does the New Johnson & Johnson Covid-19 Vaccine Work and Why is This different from mRNA Vaccines?”, you know that I think this generation of vaccines against SARS-CoV-2 is pretty special. T It is a miracle that we have this plethora of vaccines when history tells us that it is rare to even have one this soon. In a continuation of last week’s deep dive into the Johnson and Johnson vaccine, we will examine the topics discussed in the final hearing before the FDA granted Emergency Use Authorization. Topics include the vaccine efficacy in moderate and severe COVID-19 across different age groups, efficacy against the variants, and in efficacy in different regions of the world, and an explanation as to why these data points matter; its ability to confer long term immunity; the ability to stop asymptomatic transmission; the vaccine’s side effects; and its safety in children, pregnant women, and the immune compromised.

Disclaimer: I am not giving medical advice. All medical decisions need to be made by you, your doctor, and any close circle of friends and family who are your advisors. I am giving you the latest FDA recommendations and my knowledge of the immune system and science behind the medicine.

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