Episódios

  • The future of ribosomes

    The future of ribosomes
    Dec 5 2025
    Maria Barna is an authority on ribosomes – “life’s most ancient and spectacular molecular machines.” Ribosomes make proteins in the body. There can be a thousand different types of ribosomes in a single cell, she says, each with a specific job to do. But sometimes things go awry and ribosomes get “hijacked,” leading to disease. Barna studies these “diabolical” variations to find new therapies to treat diseases ranging from cancer and COVID to Parkinson’s. When diseases hit, it’s all about the ribosomes, Barna tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: ​​Maria BarnaConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Maria Barna, a professor of genetics at Stanford University.(00:04:21) Origins of Ribosome ResearchMaria explains why ribosomes became the focus of her work.(00:06:14) Ribosome Function and ScaleRibosomes’ functions and the energy required for their production.(00:08:28) Ribosomes as MachinesHow ribosomes influence which proteins are produced and when.(00:09:48) Ribosome RegulationThe regulatory layers within ribosomes and their possible variants.(00:14:35) Ribosomes and DiseaseHow ribosomal dysfunction is linked to a wide range of diseases.(00:18:16) Ribosome Mutations and DevelopmentCongenital disorders that can be attributed to specific ribosomal mutations.(00:20:44) RNA vs. Protein OutputWhy RNA measurements alone do not accurately predict protein levels.(00:24:16) Designing Ribosomes for TherapyThe potential of using engineered ribosomes for target therapies.(00:26:16) Small-Molecule Ribosome ModulatorsScreening compounds that may enhance ribosome activity for treatments.(00:28:39) Future Ribosome ProfilingIsolating individual ribosomes to understand their specific roles.(00:30:35) Future In a MinuteRapid-fire Q&A: scientific progress, community, and alternative career interest.(00:34:01) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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    35 minutos
  • Best of: How to take waste out of wastewater

    Best of: How to take waste out of wastewater
    Nov 28 2025

    In October, chemical engineer Will Tarpeh was awarded a 2025 MacArthur “Genius Grant” in recognition of his pioneering work to turn wastewater into a source of valuable materials. Will envisions a future in which the concept of wastewater is obsolete, thanks to advances in recycling. A couple of years ago, we sat down to talk with him about this work, and we hope you’ll take another listen today to learn more about the research Will is doing to transform the potential of wastewater into resources.

    Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.

    Episode Reference Links:

    • Stanford Profile: ​​William Abraham Tarpeh

    Connect With Us:

    • Episode Transcripts >>> The Future of Everything Website
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    Chapters:

    (00:00:00) Introduction

    Russ Altman introduces Will Tarpeh, a professor of chemical engineering at Stanford University.

    (00:03:01) Wastewater as a Modern Mine

    How elements like nitrogen and phosphorus can be recovered from waste.

    (00:04:15) Path to Sanitation Research

    Will shares what led to his interest in studying wastewater.

    (00:06:55) The Science of Separation

    The electrochemical and material techniques to extract valuable compounds.

    (00:08:37) Urine-Based Fertilizer

    How human urine could meet up to 30% of global fertilizer needs.

    (00:11:08) Drugs in Wastewater

    The potential of reclaiming pharmaceuticals from waste streams.

    (00:14:14) Decentralized Sanitation

    Opportunities for neighborhood or household-scale treatment systems.

    (00:16:48) Source Separation Systems

    How dividing waste at the source improves recycling and recovery.

    (00:18:56) Global Sanitation Challenges

    Ways that developing countries can adopt modern waste solutions.

    (00:23:51) Preventing Algal Blooms

    The systems that are helping to reduce nutrient pollution and dead zones.

    (00:27:16) The Urine Summit

    A community advancing urine recycling and sustainable sanitation policy.

    (00:28:43) Conclusion

    Connect With Us:

    Episode Transcripts >>> The Future of Everything Website

    Connect with Russ >>> Threads / Bluesky / Mastodon

    Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook


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    29 minutos
  • The future of digital markets

    The future of digital markets
    Nov 21 2025
    Gabriel Weintraub studies how digital markets evolve. In that regard, he says platforms like Amazon, Uber, and Airbnb have already disrupted multiple verticals through their use of data and digital technologies. Now, they face both the opportunity and the challenge of leveraging AI to further transform markets, while doing so in a responsible and accountable way. Weintraub is also applying these insights to ease friction and accelerate results in government procurement and regulation. Ultimately, we must fall in love with solving the problem, not with the technology itself, Weintraub tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Gabriel WeintraubConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Gabriel Weintraub, a professor of operations, information, and technology at Stanford University.(00:03:00) School Lunches to Digital PlatformsHow designing markets in Chile led Gabriel to study digital marketplaces.(00:03:57) What Makes a Good MarketOutlining the core principles that constitute a well-functioning market.(00:05:29) Opportunities and Challenges OnlineThe challenges associated with the vast data visibility of digital markets.(00:06:56) AI and the Future of SearchHow AI and LLMs could revolutionize digital platforms.(00:08:15) Rise of Vertical MarketplacesThe new specialized markets that curate supply and ensure quality.(00:10:23) Winners and Losers in Market ShiftsHow technology is reshaping industries from real estate to travel.(00:12:38) Government Procurement in ChileApplying market design and AI tools to Chile’s procurement system.(00:15:00) Leadership and AdoptionThe role of leadership in modernizing government systems.(00:18:59) AI in Government and RegulationUsing AI to help governments streamline complex bureaucratic systems.(00:21:45) Streamlining Construction PermitsPiloting AI tools to speed up municipal construction-permit approvals.(00:23:20) Building an AI StrategyCreating an AI strategy that aligns with business or policy goals.(00:25:26) Workforce and ExperimentationTraining employees to experiment with LLMs and explore productivity gains.(00:27:36) Humans and AI CollaborationThe importance of designing AI systems to augment human work, not replace it.(00:28:26) Future in a MinuteRapid-fire Q&A: AI’s impact, passion and resilience, and soccer dreams.(00:30:39) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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    32 minutos
  • The future of immunotherapy

    The future of immunotherapy
    Nov 14 2025
    Biochemist Lingyin Li survived breast cancer at just 30 and now works to harness the human immune system to fight cancers that have long evaded treatment. T cells, she says, are powerful cancer killers, but they can be oblivious. She and her lab colleagues have discovered a masking enzyme that squelches the immune system’s “danger signals” and are now developing drugs to block that enzyme. She likens her work to an arms race between cancer and immunotherapy. “The cancers are not getting smarter, but we are,” Li tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Lingyin LiConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Lingyin Li, a professor of biochemistry at Stanford University.(00:03:38) Research MotivationLingyin explains how her breast cancer diagnosis inspired her research.(00:04:31) How T-Cells WorkT-cell mechanisms and why they struggle to reach solid tumors.(00:05:38) Immune System OverviewInnate and adaptive immunity and how mutations make cancer recognizable.(00:07:28) Awakening the Immune SystemEfforts to stimulate innate immune cells to detect and expose tumors.(00:10:54) The Cancer SignalDiscovery of cancer-derived DNA signals that alert the immune system.(00:13:01) Cancer’s Evasion MechanismHow tumors destroy immune signals to hide from detection.(00:14:26) ENPP1 EnzymeIdentification of ENPP1 as the enzyme enabling immune evasion.(00:15:22) Balancing Immunity and SafetyRole of ENPP1 in autoimmunity and the challenge of targeting it safely.(00:19:30) ENPP1 InhibitorsDevelopment of molecules to block ENPP1 and enhance immune signaling.(00:24:55) Preclinical FindingsThe promising results against aggressive solid tumors in animal studies(00:28:05) From Lab to ClinicThe progress toward FDA approval and preparation for human testing.(00:31:04) Future In a MinuteRapid-fire Q&A: innovation, collaboration, and the outlook for cancer treatment.(00:33:14) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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    34 minutos
  • The future of emerging technologies

    The future of emerging technologies
    Nov 7 2025
    On our 300th episode, Stanford Hoover Institution Director and former U.S. Secretary of State Condoleezza Rice talks about her return to Stanford after years in government and the impact she sees rapidly advancing technologies having on democracy and public policy. She says the future demands greater collaboration among industry, academia, and government to ensure promising fields like quantum computing and AI are used for the greatest good—in education, medicine, and the sciences. We are in a race that we must win, Rice tells host Russ Altman on this special episode of Stanford Engineering’s The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Condoleezza RiceConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Condoleezza Rice, former U.S. Secretary of State and a professor of political science and political economy at Stanford University.(00:04:08) Returning to StanfordWhy Condoleezza returned to academia after serving as Secretary of State.(00:04:50) Higher Education & Public TrustPotential factors impacting universities' connection to the broader public.(00:07:31) Why Research Still MattersThe importance of curiosity-driven, federally funded university research.(00:09:32) Hoover’s Emerging Tech InitiativeAn outline of the Hoover Institution’s Tech Initiative and its policies.(00:12:11) Uniting Scientists & PolicymakersHow engineers and researchers are engaging with policy and ethics.(00:13:41) The Race For InnovationEmerging themes and key enablers in the technology innovation race.(00:19:17) Industry in the LeadHow private companies are now the primary drivers of innovation.(00:22:02) Global Tech & National InterestsThe tension between globalized tech firms and U.S. policy interests(00:24:35) AI & EducationUsing AI as a tool to enhance teaching and critical thinking in students.(00:28:30) Students Driving PolicyThe contribution students are making to Hoover’s tech policy work.(00:29:23) Future In a MinuteRapid-fire Q&A: hope, innovation, time, humanity, and alternate careers.(00:31:09) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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    32 minutos
  • The countdown to our 300th episode

    The countdown to our 300th episode
    Nov 5 2025

    Tune in on Friday, November 7th to listen to our 300th episode with a very special guest.

    Connect With Us:

    Episode Transcripts >>> The Future of Everything Website

    Connect with Russ >>> Threads / Bluesky / Mastodon

    Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook


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    Menos de 1 minuto
  • Best of: The future of transparent tissue

    Best of: The future of transparent tissue
    Oct 31 2025
    About a year ago, a research team at Stanford Engineering led by Guosong Hong published a paper about their work to use a common food dye to make mouse skin transparent. Their findings made a big splash and have the potential to provide a range of benefits in health care. You can imagine that if we have the ability to see what’s going on under the skin without having to cut into it, or use radiation to get a clear look, this could improve everything from invasive biopsies to painful blood draws. We hope you’ll tune in again and enjoy.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: ​​Guosong HongGuosong's Lab: THE HONG LABConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Guosong Hong, an expert in physics, material science, and biology from Stanford University.(00:01:52) Material Science Meets NeuroscienceHow Guosong’s research blends nanomaterials and brain science.(00:03:00) Why Tissue Isn’t TransparentThe challenge of light penetration in biological tissues.(00:04:54) A New Approach to Tissue ClearingThe physics behind tissue transparency and refractive index manipulation.(00:07:57) UV Light and TransparencyHow manipulating UV absorption can align refractive indexes.(00:10:16) First Experiments and ResultsInitial tests that demonstrate successful tissue clearing.(00:12:19) Applications in MedicineThe potential of transparent tissues in dermatology and medical imaging.(00:14:36) Testing on Live TissueThe results of testing transparency techniques on live mice.(00:18:30) Transparency in NatureHow some species have naturally transparent tissue.(00:19:52) Human Eye and Protein TransparencyThe unique proteins that keep our lenses clear using similar physics.(00:22:24) Wireless Light Inside the BodyDeveloping ultrasound-activated light sources for tissue imaging.(00:24:55) Precision of Ultrasound LightHow precisely ultrasound can trigger tiny particles to emit light.(00:28:14) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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    29 minutos
  • The future of wound healing

    The future of wound healing
    Oct 24 2025

    Clinician-scientist Jill Helms is an expert on healing. Until about age 30, people heal easily, she says, but later on, not so well. Regenerative medicine suggests avenues for improvement, she promises. Her research focuses on understanding the physical and molecular processes of healing to design better therapies. One approach awakens “sleeper” stem cells to aid healing, a new drug in trial regenerates bone, and another avenue targets infections that appear near medical devices using gum-like tissues that create sealing barriers. In many ways, nature remains our best model for healing, Helms tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

    Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.

    Episode Reference Links:

    • Stanford Profile: Jill Helms

    Connect With Us:

    • Episode Transcripts >>> The Future of Everything Website
    • Connect with Russ >>> Threads / Bluesky / Mastodon
    • Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook

    Chapters:

    (00:00:00) Introduction

    Russ Altman introduces guest Jill Helms, a professor of surgery at Stanford University.

    (00:03:42) Why Study Wound Healing

    Jill shares what led her to explore how the body repairs itself after injury.

    (00:04:23) How Healing Works

    Explanation of physical signals, stem cells, and the stages of tissue repair.

    (00:07:23) Healing Declines with Age

    How healing quality and speed drop significantly after age thirty.

    (00:10:48) Physical vs. Biological Signals

    The biological and physical signals that work together to guide healing.

    (00:13:21) Regenerative Medicine

    Therapies designed to restore healing capacity and accelerate repair.

    (00:16:55) Infection and Implants

    Challenges of preventing infections around skin penetrating medical devices.

    (00:21:54) Nature’s Blueprint

    Using biological models to inspire self-renewing wound interfaces.

    (00:26:19) Biomimicry and Evolutionary Insight

    What scientists are learning from animals to inform human tissue repair.

    (00:30:51) Future In a Minute

    Rapid-fire Q&A: scientific curiosity, young researchers, and supportive environments.

    (00:33:04) Conclusion

    Connect With Us:

    Episode Transcripts >>> The Future of Everything Website

    Connect with Russ >>> Threads / Bluesky / Mastodon

    Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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    34 minutos