Still Alice the book, sold 1M copies worldwide – a national bestseller. Still Alice the movie, sold $45M worth of tickets at the box office – and won an Academy Award. But back when neuroscientist Lisa Genova first penned the novel, it was rejected by 100 book agents. She was told no one would read a book about Alzheimer’s Disease, that the subject matter was too depressing and that neuroscientists shouldn’t write fiction.

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Cuban pitcher Yennier Cano was told he’d never make the Cuban National Series. Then when he tried to leave Cuba to play in the Majors, his government banned him from playing baseball. When he finally made it to America, Cano floundered in obscurity in the minors. Today he’s one of the best relievers in Major League Baseball.

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Cataracts are the leading cause of blindness worldwide – 50% of the world’s blindness is a result of cataracts. For 200 years, treatment of the condition involved removing the lens of the eye and substituting the function of that lens with a pair of thick glasses. But in 1949, Dr. Harold Ridley had another idea. What if he replaced the natural lens of the eye with an artificial one? Well, let’s just say the field of ophthalmology didn’t see the vision.

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