Plagues, pandemics, and infectious diseases have shaped the history of the Jewish people. Of course, there were the ten biblical plagues that famously smote the Egyptians—from the rain of frogs to the deaths of the firstborn—but that is just the start of the story. For the Talmudic Sages infectious diseases were part of the fundamental fabric of God's created world. In later times, however, disease was often thought to be caused by malign spells and incantations. A counter-magic developed to combat them. Amulets were deployed and miracle workers sought out. Surprisingly, Jeremy Brown shows, Jews sometimes even visited Christian shrines and beseeched the intervention of their saints. In 1348, when the Black Death swept through Europe, Jews fell victim both to the disease, for which they were blamed, and to the anti-Semitic violence that followed.

In The Eleventh Plague, Brown investigates the relation between Judaism and infectious diseases throughout the ages, from premodern and early-modern plagues, to rabbinic responses to smallpox and cholera, and to the curious practice of "Black Weddings" in which two orphans are married in a cemetery. Popularized during the 1918 influenza pandemic, the practice was revived in response to the COVID-19 pandemic, showing that the intriguing relationship between Judaism and infectious disease remains relevant today.